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Nonparametric estimation of potency ratio for dilution assays

โœ Scribed by Mohamed A.A. Moussa

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
448 KB
Volume
23
Category
Article
ISSN
0010-4825

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โœฆ Synopsis

The paper considers the estimation of the potency of an unknown test preparation in relation to a standard in a dilution assay. The method utilizes the Mantel-Haenszel one degree of freedom chi-square approach to test consistency of the observed potency ratio with a range of alternative potency ratios. The method is nonparametric as it does not require any distributional assumptions. However, it requires the doses employed to be equally spaced logarithmically. The dose-response curve is also required to be monotone over the dose range used.

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