## Abstract The monoamine oxidase inhibitors pargyline and clorgyline have been synthesized by methylation of the appropriate secondary propargylamines, using [^14^C]dimethyl sulphate. This simple method should be generally applicable to other compounds of this class.
The estimation of monoamine oxidase using 14C-labelled substrates
✍ Scribed by Jennifer Southgate; G.G.S. Collins
- Book ID
- 115770278
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- English
- Weight
- 232 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0006-2952
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## Abstract N‐[3‐(2,4‐dichlorophenoxy)propyl]‐N‐methyl‐2‐propynylamine‐1‐^14^C (^14^C‐clorgyline, **1a**) and L‐N, α‐dimethyl‐N‐2‐propynyl‐1‐^14^C‐phenethylamine (^14^C‐L deprenyl, **1b**) were synthesized by the Mannich reaction of 2‐methyl‐3‐butyn‐2‐ol, ^14^C‐formaldehyde, and secondary amines 3‐
a m i n e a n d N-methylphenethyl amine as well as the 14C-labeling of c l o r g y l i n e a n d L -d e p r e n y l a r e d e s c r i b e d . L a b e l i n g was a c c o m p l i s h e d b y N -a l k y l a t l o n o f t h e f r e e b a s e o f t h e c o r r e s p o n d i n g d e s m e t h y l c o m p