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The essentiality of calcium ion in the enzymatic activity of Taiwan cobra phospholipase A2

โœ Scribed by Long-Sen Chang; Shinne-Ren Lin; Chun-Chang Chang

Publisher
Springer
Year
1996
Tongue
English
Weight
515 KB
Volume
15
Category
Article
ISSN
1573-4943

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The structural and functional contributi
The structural and functional contribution of N-terminal region and His-47 on Taiwan cobra phospholipase A2
โœ Pei-Hsiu Kao; Ku-Chung Chen; Shinne-Ren Lin; Long-Sen Chang ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 384 KB

Modification of His-47 and removal of the N-terminal octapeptide caused a different effect on the structure of Naja naja atra (Taiwan cobra) phospholipase A2 (PLA2). Unlike native enzyme, Ca2+ induced an alteration in the structural flexibility of His-modified PLA2. Moreover, the spatial positions o