Two novel analogues of lysine have been prepared in high enantiomeric and diastereomeric purity. These unnatural a-amino acids possess modified aminoalkyl side chains incorporating a pyrrolidine nucleus as a cyclic constraint.
The enantiospecific synthesis of functionalised pipecolic acids as constrained analogues of lysine
β Scribed by Peter John Murray; Ian D. Starkey
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 220 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
A simple synthesis of various 6-amino-2-substitutcd hexanoic acids has been developed starting from lysine via the triflate of 6-amino-2-hydroxy hexanoic acid. The same reactions have also been successfully applied starting from the lysyl-proline sequence. The lysine analogues have been introduced i
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