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The enantiospecific synthesis of functionalised pipecolic acids as constrained analogues of lysine

✍ Scribed by Peter John Murray; Ian D. Starkey


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
220 KB
Volume
37
Category
Article
ISSN
0040-4039

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The enantiospecific synthesis of novel l
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Two novel analogues of lysine have been prepared in high enantiomeric and diastereomeric purity. These unnatural a-amino acids possess modified aminoalkyl side chains incorporating a pyrrolidine nucleus as a cyclic constraint.

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A simple synthesis of various 6-amino-2-substitutcd hexanoic acids has been developed starting from lysine via the triflate of 6-amino-2-hydroxy hexanoic acid. The same reactions have also been successfully applied starting from the lysyl-proline sequence. The lysine analogues have been introduced i

ChemInform Abstract: Triflates as Syntho
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v