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Chemoenzymatic Synthesis of Phosphonic Acid Analogues of L-Lysine, L-Proline, L-Ornithine, and L-Pipecolic Acid of 99 % ee – Assignment of Absolute Configuration to (–)-Proline

✍ Scribed by Frank Wuggenig; Anna Schweifer; Kurt Mereiter; Friedrich Hammerschmidt


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
660 KB
Volume
2011
Category
Article
ISSN
1434-193X

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Two mutant Chinese hamster lung fibroblast lines have been isolated that are resistant to the the toxic proline analog L-azetidine-2-carboxylic acid. The line designated AZCA-1 has 30-fold elevated activity of pyrroline-5-carboxylate synthase and a large increase in the rate of proline production an