The enantioselective total synthesis of the antitumor macrolide natural product rhizoxin D

✍ Scribed by Jennifer A. Lafontaine; David P. Provencal; Cristina Gardelli; James W. Leahy

• Book ID: 104261514
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 291 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00731-5

✦ Synopsis

A convergent, enantioselective total synthesis of rhizoxin D (didesepoxyrhizoxin), a potent antitumor natural product, was achieved via three critical olefinations, including a Horner-Emmons macrocyclization.