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Stereoselective Total Synthesis of Antitumor Macrolide (+)-Rhizoxin D †

✍ Scribed by Jiang, Yueheng; Hong, Jian; Burke, Steven D.


Book ID
120629024
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
91 KB
Volume
6
Category
Article
ISSN
1523-7060

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The enantioselective total synthesis of
✍ Jennifer A. Lafontaine; David P. Provencal; Cristina Gardelli; James W. Leahy 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 291 KB

A convergent, enantioselective total synthesis of rhizoxin D (didesepoxyrhizoxin), a potent antitumor natural product, was achieved via three critical olefinations, including a Horner-Emmons macrocyclization.