The Enantioselective, Brønsted Acid Catalyzed, Vinylogous Mannich Reaction
✍ Scribed by Marcel Sickert; Christoph Schneider
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 324 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0044-8249
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📜 SIMILAR VOLUMES
HBF 4 -catalyzed Mannich-type reaction of silyl enolates with aldimines took place smoothly in aqueous organic solvent to afford b-aminocarbonyl compounds in high yields. The HBF 4 -catalyzed Mannich-type reaction also proceeded smoothly in water without organic solvent in the presence of a surfacta
## Abstract A novel cyclic dialkyl phosphate was synthesized starting from (+)‐diethyl tartrate. Its catalytic activity as a chiral Brønsted acid has been examined in the Mannich‐type reaction of a ketene silyl acetal with aldimines as a model reaction. The corresponding β‐amino acid esters were ob