𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enantioselective Mannich-Type Reaction Catalyzed by a Chiral Brønsted Acid Derived from TADDOL

✍ Scribed by Takahiko Akiyama; Youichi Saitoh; Hisashi Morita; Kohei Fuchibe

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
83 KB
Volume
347
Category
Article
ISSN
1615-4150

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A novel cyclic dialkyl phosphate was synthesized starting from (+)‐diethyl tartrate. Its catalytic activity as a chiral Brønsted acid has been examined in the Mannich‐type reaction of a ketene silyl acetal with aldimines as a model reaction. The corresponding β‐amino acid esters were obtained with high enantioselectivity.

📜 SIMILAR VOLUMES

High Substrate/Catalyst Organocatalysis
High Substrate/Catalyst Organocatalysis by a Chiral Brønsted Acid for an Enantioselective Aza-Ene-Type Reaction
✍ Masahiro Terada; Kyoko Machioka; Keiichi Sorimachi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB

The enantioselective catalysis of organic reactions that involve small organic molecules, known as organocatalysis, has become a rapidly growing area of research, as it offers operational simplicity together with mild reaction conditions and is environmentally benign. [1] Although organocatalysis ha