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The effects of protriptyline and clomipraminein vitroon the uptake of 5-hydroxytryptamine and dopamine in human platelet-rich plasma

✍ Scribed by Ann Trenchard; P. Turner; C. M. B. Pare; M. Hills

Publisher: Springer
Year: 1975
Tongue: English
Weight: 371 KB
Volume: 43
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00437621

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✦ Synopsis

The effects of protriptyline and clomipramine, at concentrations of 10(-7)M to 10(-4)M, were studied in vitro on the uptake of 5-hydroxytryptamine and dopamine uptake in human platelet-rich plasma. It was found that the tertiary amine, clomipramine, was a more potent inhibitor of 5-hydroxytryptamine uptake than the secondary amine, protriptyline. The activity of both compounds was competitive but it was thought unlikely that they acted through tryptamine receptor sites as methysergide 2.5 X 10(-8)M had very little effect on 5-hydroxytryptamine uptake. Neither tricyclic antidepressant had any marked effect on dopamine uptake.

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