Effects of some β-carbolines on the concentrations of 5-hydroxytryptamine, dopamine, and some related metabolites in the cerebral ganglia of the cockroach (Periplaneta americana)
✍ Scribed by Sloley, B. Duff
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 447 KB
- Volume
- 248
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
The effects of the p-carbolines, harmaline, harmalol, harmane, and harmine on 5-hydroxytryptamine, dopamine, and tryptophan concentrations in the cerebral ganglion of the cockroach (Periplanela americana) were investigated. Injections of harmaline and harmine-induced decreases in the concentrations of 5-hydroxytryptamine and dopamine. The 5-hydroxytryptamine depletion was greater than the dopamine depletion. Injections of harmalol had no effect. Tryptophan concentrations were variable, although significant decreases were observed in harmaline-treated animals. N-acetyl 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, and 5-hydroxytryptophan remained below the level of detection in all tissues examined, indicating that these compounds do not accumulate within the central nervous system as a result of the various treatments.