𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effects of naloxone on opiate and placebo analgesia in healthy volunteers

✍ Scribed by J. Posner; C. A. Burke

Publisher
Springer
Year
1985
Tongue
English
Weight
532 KB
Volume
87
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

Two double blind cross-over studies were performed using a submaximal effort tourniquet test (SETT) in healthy volunteers to investigate the role of endogenous opioids in placebo analgesia. In the first study IV naloxone significantly inhibited analgesia, miosis and sedation produced by the opioid dipipanone 10 mg in 12 subjects. In the second naloxone, which did not produce hyperalgesia, failed to inhibit significant placebo analgesia in 12 subjects. The results do not support the involvement of endogenous opioids in ischemic limb pain or placebo analgesia under these conditions.

πŸ“œ SIMILAR VOLUMES

A comparison of the effect of lofepramin
A comparison of the effect of lofepramine, maprotiline and placebo on information processing in healthy volunteers
✍ H. Hopes; J. Wandmacher πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 615 KB

Single oral doses of lofepramine (140 mg), maprotiline (100 mg), and placebo were administered in a randomized three-way crossover design with 1 week wash-out between administrations to 12 healthy male volunteers. Before, and 1, and 3 h post-administration a battery of performance tests was administ

Lack of effects between rupatadine 10 mg
Lack of effects between rupatadine 10 mg and placebo on actual driving performance of healthy volunteers
✍ Eric Vuurman; Eef Theunissen; Anita van Oers; Cees van Leeuwen; Jelle Jolles πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 125 KB

## Abstract ## Introduction Rupatadine fumarate is a potent, selective, histamine H~1~‐receptor antagonist and PAF inhibitor with demonstrated efficacy for the relief of allergic rhinitis. Rupatadine does not easily cross the blood–brain barrier and is believed to be non‐sedating at therapeutic do

The effects of acute treatment with tand
The effects of acute treatment with tandospirone, diazepam, and placebo on driving performance and cognitive function in healthy volunteers
✍ Masahiro Takahashi; Kunihiro Iwamoto; Yukiko Kawamura; Yukako Nakamura; Ryoko Is πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 117 KB πŸ‘ 2 views

## Abstract ## Objective To assess the effects of two anxiolytics, diazepam and tandospirone, on driving performance from methodological viewpoints taking frequent rear‐end collisions into account. ## Methods In this double‐blinded, three‐way crossover trial, 18 healthy males received acute dose

Effects of single and multiple doses of
Effects of single and multiple doses of dexnafenodone, imipramine and placebo on sleep of young healthy volunteers
✍ H. Schulz; U. Legler; M. Jobert; G. Greger πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 414 KB πŸ‘ 2 views

The effects on polygraphically recorded sleep of single and repeated doses of dexnafenodone (20 mg daily) were determined in 12 young, healthy subjects, and compared to those of imipramine (75 mg daily: six subjects) and placebo (six subjects). After two adaptation nights, sleep was recorded at base

The psychomotor and cognitive effects of
The psychomotor and cognitive effects of a new antihistamine, mizolastine, compared to terfenadine, triprolidine and placebo in healthy volunteers
✍ J. S. Kerr; I. Hindmarch; C. Dunmore πŸ“‚ Article πŸ“… 1994 πŸ› Springer 🌐 English βš– 474 KB

Eighteen healthy volunteers received mizolastine 5 mg, 15 mg or 45 mg, terfenadine 60 mg, triprolidine 10 mg or placebo in a 6-way crossover, double blind study. Following each dose, subjects performed a series of tests of cognitive function and psychomotor performance at 1, 3, 5, 8 and 24 hours pos