## Abstract ## Objective To determine if folinic acid supplementation during methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduces both urinary 5βaminoimidazoleβ4βcarboxamide (AICA) and urinary adenosine excretion more than does folic acid supplementation. AICA and adenosine are markers
The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients
β Scribed by Moshe Tishler; Dan Caspi; Beno Fishel; Michael Yaron
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 259 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0004-3591
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π SIMILAR VOLUMES
Objective. To evaluate the influence of food on the bioavailability of an oral dose of methotrexate in patients with rheumatoid arthritis. Methods. Methotrexate (15 mg) was given intravenously and orally, with or without a meal, to 10 patients. Blood samples were drawn at specific intervals to eval
## Abstract ## Objective The risk of lymphoma is increased in patients with rheumatoid arthritis (RA), and spontaneous reporting suggests that methotrexate (MTX) and antiβtumor necrosis factor (antiβTNF) therapy might be associated independently with an increased risk of lymphoma. However, data fr