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Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis

✍ Scribed by Gideon Nesher; Michal Mates; Shoshana Zevin

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
38 KB
Volume
48
Category
Article
ISSN
0004-3591

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Objective. To evaluate the influence of food on the bioavailability of an oral dose of methotrexate in patients with rheumatoid arthritis. Methods. Methotrexate (15 mg) was given intravenously and orally, with or without a meal, to 10 patients. Blood samples were drawn at specific intervals to eval

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Patients with rheumatoid arthritis who are unresponsive to antiinflammatory drugs and slow-acting agents such as gold, hydroxychloroquine, and Dpenicillamine, pose a therapeutic challenge. This report details the effectiveness of weekly intravenous methotrexate in 14 such patients resistant to stand