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Effect of food on the bioavailability of low-dose methotrexate in patients with rheumatoid arthritis

✍ Scribed by D. Oguey; F. Kölliker; N. J. Gerber; J. Reichen

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
355 KB
Volume
35
Category
Article
ISSN
0004-3591

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✦ Synopsis

Objective. To evaluate the influence of food on the bioavailability of an oral dose of methotrexate in patients with rheumatoid arthritis.

Methods. Methotrexate (15 mg) was given intravenously and orally, with or without a meal, to 10 patients. Blood samples were drawn at specific intervals to evaluate drug levels.

Results. Food reduced the peak concentration, from a mean of 0.71 pmoleshiter to 0.49 pmoles/liter (P < 0.02), and slightly increased the time to peak concentration, from a mean of 1.3 hours to 2.0 hours. Bioavailability was highly variable (range 28-9470) but was not affected by food intake.

Conclusion.

Bioavailability of oral methotrexate shows marked interindividual variation but is not affected by the presence of food.

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The effects of non-steroidal anti-inflam
The effects of non-steroidal anti-inflammatory drugs on the disposition of methotrexate in patients with rheumatoid arthritis
✍ M. Perwaiz Iqbal; Javed A. Baig; Azra A. Ali; Sarfaraz K. Niazi; N. Mehboobali; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 2 views

We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently taking the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, diclofenac, naproxen, indomethacin, and ibuprofen. The area under the curve, the total systemic clearance, t