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Chloroquine reduces the bioavailability of methotrexate in patients with rheumatoid arthritis

✍ Scribed by Peter Seideman; Freidoun Albertioni; Olof Beck; Staffan Eksborg; Curt Peterson


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
386 KB
Volume
37
Category
Article
ISSN
0004-3591

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Objective. To evaluate the influence of food on the bioavailability of an oral dose of methotrexate in patients with rheumatoid arthritis. Methods. Methotrexate (15 mg) was given intravenously and orally, with or without a meal, to 10 patients. Blood samples were drawn at specific intervals to eval

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## Abstract ## Objective There is evidence supporting a therapeutic range for methotrexate polyglutamate (MTXGlu) concentrations in the treatment of rheumatoid arthritis (RA). Knowledge of the pharmacokinetics of MTXGlu~1–5~ is required for optimal timing of blood sampling. The aim of this study w