## BACKGROUND. Testicular dysfunction with elevated follicle-stimulating hormone (FSH) levels (indicating oligospermia and/or azoospermia) is a major late sequelae after treatment for Hodgkin's disease (HD) with high cumulative doses of procarbazine, cyclophosphamide, or chlorambucil. Etoposide is
The effects of Hodgkin's disease and combination chemotherapy on gonadal function in the adult male
β Scribed by E. Whitehead; S. M. Shalet; G. Blackledge; I. Todd; D. Crowther; C. G. Beardwell
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 494 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0008-543X
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Blood lymphocytes from 20 untreated patients with Hodgkin's disease were compared with those of 20 untreated patients with non-Hodgkin's lymphoma with regard to the responsiveness of the cells to PHA and ConA following exposure to varying doses of ionizing radiation in vitro. Lymphocytes from 19 of
Blood lymphocytes from 10 untreated patients with active Hodgkin's disease were compared with those of 10 cured patients with regard to the responsiveness of the cells to PHA and Con A following in vitro irradiation. Lymphocytes of patients remaining in long-term remission exhibited the same pattern