The effect of in vitro irradiation on mitogenic responsiveness of peripheral blood lymphocytes from untreated patients with hodgkin's disease and non-hodgkin's lymphoma

✍ Scribed by Samuel Rotstein; Edward Baral; Henric Blomgren; Bo Johansson

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 381 KB
• Volume: 50
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19820901)50:5<900::aid-cncr2820500516>3.0.co;2-9

✦ Synopsis

Blood lymphocytes from 20 untreated patients with Hodgkin's disease were compared with those of 20 untreated patients with non-Hodgkin's lymphoma with regard to the responsiveness of the cells to PHA and ConA following exposure to varying doses of ionizing radiation in vitro. Lymphocytes from 19 of the non-Hodgkin's lymphoma patients exhibited the same pattern of radiosensitivity as those of healthy donors, i.e., there was one relatively radiosensitive and one relatively resistant cell population. The latter cell population was undetectable in patients with Hodgkin's disease.

Cancer 50:900-903, 1982.

MMUNOLOGICAL ABNORMALITIES are frequently ob-I served in patients with Hodgkin's disease and also, although less frequently, in non-Hodgkin's lymphomas. 1.28.33 Recently, it was observed that the PHA and ConA reactive blood lymphocytes in HD display an increased sensitivity to ionizing radiation in vitro.' More precisely, the mitogen reactive peripheral lymphocyte population of healthy subjects is composed of one relatively radiosensitive and one relatively radioresistant s~bpopulation.'~~ The latter subpopulation was not detected in the previously examined patients with untreated Hodgkin's disease.' This particular feature was not observed in HD patients remaining in long-term remission." or in patients with gynecologic cancers,8 whose blood lymphocyte exhibited a radiosensitivity pattern similar to that of healthy controls.

The aim of the current investigation was to further examine whether the radiosensitivity pattern of blood lymphocytes from patients with active H D is restricted to this disease or whether it is also present in patients with non-Hodgkin's lymphoma.

(HD)2-5,1 1.14.17.18.20. 22-27.29,35