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The effects of glycosaminoglycans, pyrophosphate and allopurinol treatment on urease-induced crystallization in vitro

✍ Scribed by Hedelin, H. ;Grenabo, L. ;Pettersson, S.

Publisher
Springer
Year
1986
Tongue
English
Weight
309 KB
Volume
14
Category
Article
ISSN
0300-5623

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✦ Synopsis

Previous studies have found that human urine inhibits urease-induced crystallization in synthetic urine. To identify the inhibitory components the effects of chondroitin sulphate, heparin and pyrophosphate on urease-induced crystallization were studied and the inhibitory capacity of human urine collected during and before/after allopurinol treatment compared. None of the substances studied nor allopurinol treatment was found to influence the urease-induced crystallization. These findings do not support the idea that glycosaminoglycans or pyrophosphate are responsible for the inhibitory effect detected in human urine.

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