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Effects of glycosaminoglycans and proteoglycan on the in vitro assembly and thermal stability of collagen fibrils

✍ Scribed by John McK. Snowden; David A. Swann

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
818 KB
Volume
19
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The effects of three glycosaminoglycans (chondroitin 6‐sulfate, dermatan sulfate, and hyaluronate) and a proteoglycan on the kinetics of fibril formation and on the thermal stability of the in vitro assembled collagen fibrils, under physiological conditions of ionic strength and pH, have been examined. The glycosaminoglycans were found to influence the kinetics of collagen precipitation but not the thermal stability of the in vitro assembled fibrils. The proteoglycan was found to influence the kinetics of collagen precipitation and to reduce the thermal stability of the in vitro assembled fibrils. Comparison of the interaction occurring between chondroitin 6‐sulfate and collagen under acidic conditions (0.05__M__ acetic acid) and that occurring under physiological conditions showed that markedly different interaction products were formed under the different conditions.

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