𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis

✍ Scribed by T. S. Tracy; K. Krohn; D. R. Jones; J. D. Bradley; S. D. Hall; D. C. Brater

Publisher
Springer
Year
1992
Tongue
English
Weight
591 KB
Volume
42
Category
Article
ISSN
0031-6970

No coin nor oath required. For personal study only.

✦ Synopsis

We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment). The apparent systemic clearance of methotrexate was significantly reduced by all three treatments. Trisalicylate and ibuprofen both significantly reduced methotrexate renal clearance, but only the trisalicylate significantly displaced methotrexate from protein, increasing the fraction unbound by 28%. These data show that NSAIDs can affect the disposition of methotrexate, possibly increasing the potential for toxicity and necessitating dosage adjustments. However, large inter-subject variability precludes specific dosage recommendations.

πŸ“œ SIMILAR VOLUMES

The effects of non-steroidal anti-inflam
The effects of non-steroidal anti-inflammatory drugs on the disposition of methotrexate in patients with rheumatoid arthritis
✍ M. Perwaiz Iqbal; Javed A. Baig; Azra A. Ali; Sarfaraz K. Niazi; N. Mehboobali; πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 117 KB πŸ‘ 3 views

We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently taking the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, diclofenac, naproxen, indomethacin, and ibuprofen. The area under the curve, the total systemic clearance, t

A controlled study of concurrent therapy
A controlled study of concurrent therapy with a nonacetylated salicylate and naproxen in rheumatoid arthritis
✍ Daniel E. Furst; Kenneth Blocka; Sidney Cassell; E. Robert Harris; Joel M. Hirsc πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 911 KB

Previous studies of combinations of nonsteroidal drugs used in the treatment of rheumatoid arthritis (RA) have yielded conflicting results. We used standard methods to measure disease activity and high pressure liquid chromatography to measure plasma drug concentrations. We used doses of choline mag

Effect of food on the bioavailability of
Effect of food on the bioavailability of low-dose methotrexate in patients with rheumatoid arthritis
✍ D. Oguey; F. KΓΆlliker; N. J. Gerber; J. Reichen πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 355 KB πŸ‘ 2 views

Objective. To evaluate the influence of food on the bioavailability of an oral dose of methotrexate in patients with rheumatoid arthritis. Methods. Methotrexate (15 mg) was given intravenously and orally, with or without a meal, to 10 patients. Blood samples were drawn at specific intervals to eval