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The effect of α- and γ-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation

✍ Scribed by Francesco Galli; Anna Maria Stabile; Michele Betti; Carmela Conte; Allesandra Pistilli; Mario Rende; Ardesio Floridi; Angelo Azzi

Book ID
116176872
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
187 KB
Volume
423
Category
Article
ISSN
0003-9861

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The metabolites are 2,5,7,8-tetramethyl-2-(2-carboxyethyl)-6-hydroxychroman (␣-CEHC) and 2,7,8-trimethyl-2-(2carboxyethyl)-6-hydroxychroman (␥-CEHC, LLU-␣), respectively. ␣-CEHC is excreted mainly as glucuronide or sulfate conjugates in the urine. Here we describe a sensitive and reliable method to