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The effect of TN-16 on the alkylation of tubulin

โœ Scribed by Mary Carmen Roach; Richard F. Luduena

Book ID
115758933
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
425 KB
Volume
129
Category
Article
ISSN
0006-291X

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Diethylstilbestrol is a drug used to treat prostate cancer. It is thought to bind to tubulin, the subunit protein of microtubules, at the colchicine-binding site. We examined its interaction with tubulin in more detail. Diethylstilbestrol inhibits microtubule assembly, and seems to do so more effect