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Effect of phomopsin a on the alkylation of tubulin

✍ Scribed by Richard F. Ludueña; Mary Carmen Roach; Veena Prasad; Ernest Lacey

Book ID
115781771
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
644 KB
Volume
39
Category
Article
ISSN
0006-2952

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✍ Veena Prasad; Stuart E. Garber; Richard F. Ludueña 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB 👁 2 views

Diethylstilbestrol is a drug used to treat prostate cancer. It is thought to bind to tubulin, the subunit protein of microtubules, at the colchicine-binding site. We examined its interaction with tubulin in more detail. Diethylstilbestrol inhibits microtubule assembly, and seems to do so more effect