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Interaction of tubulin with drugs and alkylating agents. 2. Effects of colchicine, podophyllotoxin, and vinblastine on the alkylation of tubulin

✍ Scribed by Luduena, Richard F.; Roach, Mary Carmen

Book ID
126209574
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
979 KB
Volume
20
Category
Article
ISSN
0006-2960

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Diethylstilbestrol is a drug used to treat prostate cancer. It is thought to bind to tubulin, the subunit protein of microtubules, at the colchicine-binding site. We examined its interaction with tubulin in more detail. Diethylstilbestrol inhibits microtubule assembly, and seems to do so more effect