The Effect of the Bite Angle of Diphosphane Ligands on Activity and Selectivity in Palladium-Catalyzed Allylic Alkylation

✍ Scribed by Mirko Kranenburg; Paul C. J. Kamer; Piet W. N. M. van Leeuwen

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 295 KB
• Volume: 1998
• Category: Article
• ISSN: 1434-1948
• DOI: 10.1002/(sici)1099-0682(199801)1998:1<25::aid-ejic25>3.0.co;2-k

✦ Synopsis

The effect of the natural bite angle (β n ) of diphosphane li-angle of the ligand becomes larger. This results in an increasing selectivity at larger bite angles, but at very large gands on catalyst selectivity and activity in the palladiumcatalyzed allylic alkylation was investigated. The selectivity bite angles the rate of the reaction drops. The ligand with the largest calculated bite angle, Xantphos, induced 100% and rate of the reaction are mainly determined by steric hindrance induced by the diphosphane ligands. The steric hin-selectivity but the reaction rate became low. drance at the palladium center increases as the natural bite