THE EFFECT OF NALORPHINE ON THE ANTIDIURETIC ACTION OF MORPHINE IN RATS AND MEN
β Scribed by SCHNIEDEN, H. ;BLACKMORE, E. K.
- Book ID
- 117955037
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1955
- Weight
- 806 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0366-0826
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The effects of morphine (10 mg/kg), nalorphine (1 and 10 mg/kg), and naloxone (1 mg/kg) were studied on the neoeortical release of aeetylcholine (ACh) in midpontine pretrigeminal transected rats. Morphine and, to a lesser extent, nalorphine decreased ACh release. Naloxone was ineffective alone but a
Intraventricular administration of kainic acid at the dose of 0.1 pg induces a significant depression of rectal temperature followed rapidly by its slight elevation. Morphine (40.0 rag. kg-1 IP), which by itself elicited biphasic effect on the body temperature of rats-initially hypothermia followed