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Effects of morphine and nalorphine on kainic acid-induced hypothermia in rats

✍ Scribed by Lechosław Turski; Waldemar Turski; Stanisław J. Czuczwar; Zdzisław Kleinrok

Publisher
Springer
Year
1981
Tongue
English
Weight
328 KB
Volume
72
Category
Article
ISSN
0033-3158

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✦ Synopsis

Intraventricular administration of kainic acid at the dose of 0.1 pg induces a significant depression of rectal temperature followed rapidly by its slight elevation. Morphine (40.0 rag. kg-1 IP), which by itself elicited biphasic effect on the body temperature of rats-initially hypothermia followed by hyperthermia-slightly increased the kainic acid-induced hypothermia. Kainic acid did not cause any changes in the hyperthermic effect of low doses of morphine (10.0 rag. kg-1). Pretreatment of rats with nalorphine enhanced the kainic acid-induced hypothermia. On the contrary, nalorphine reversed the hypothermic effect produced by morphine at the dose of 40.0 mg.kg-2. The results suggest that morphine and kainic acidinduced hypothermia are not mediated by the influence on the same type of receptors.

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