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The effect of methylxanthines on chromosomes of human lymphocytes in culture

✍ Scribed by David Weinstein; Irving Mauer; Marion L. Katz; Sonja Kazmer


Book ID
119091513
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
333 KB
Volume
31
Category
Article
ISSN
0165-1161

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In this study the clastogenic effect of pyrimethamine (Daraprim), a folic acid antagonist used for the treatment of toxoplasmosis and malaria on human chromosomes, was investigated. Pyrimethamine was added to in vitro lymphocyte cultures at six different concentrations: 0.05 (normal therapeutic dose