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The Clastogenic effect of Pyrimethamine (Daraprim) on human chromosomes in lymphocyte cultures

✍ Scribed by Ü. Egeli; G. Erdogan

Publisher
Springer
Year
1991
Tongue
English
Weight
973 KB
Volume
7
Category
Article
ISSN
0742-2091

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✦ Synopsis

In this study the clastogenic effect of pyrimethamine (Daraprim), a folic acid antagonist used for the treatment of toxoplasmosis and malaria on human chromosomes, was investigated. Pyrimethamine was added to in vitro lymphocyte cultures at six different concentrations: 0.05 (normal therapeutic dose), 0.1, 0.2, 0.4, 0.8, and 1.6 mg/ml. No proliferation was observed in any of the cultures containing 1.6 mg/ml pyrimethamine. The results of the cytogenetic evaluations show that the frequency of breaks and gaps increase significantly in dose-dePendent manner. Thus, pyrimethamine has a clastogenic effect on human chromosomes.

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