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The effect of hypoxia on propranolol clearance during antegrade and retrograde flow in the isolated perfused rat liver preparation

โœ Scribed by Susan L. Elliott; Denis J. Morgan; Peter W. Angus; Hany Ghabrial; R.G.Peter Watson; Richard A. Smallwood

Book ID
115783223
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
884 KB
Volume
45
Category
Article
ISSN
0006-2952

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Differential Effects of Hypoxia on the D
Differential Effects of Hypoxia on the Disposition of Propranolol and Sodium Taurocholate by the Isolated Perfused Rat Liver
โœ D. Brian Jones; George W. Mihaly; Richard A. Smallwood; Lorraine K. Webster; Den ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 715 KB

Although the adverse effect of hypoxia on drug metabolism is well documented in subcellular systems, its effect on drug clearance by the intact liver has not been defined. This study was undertaken in the isolated perfused rat liver to examine the effects of acute hypoxia on the hepatic elimination