Using the isolated perfused neonatal sheep liver model, we examined the disposition of propranolol (n โซืกโฌ 8, age 0.25-10 days) and compared our findings with our previous study from the perfused near-term fetal sheep liver (Ring JA, et al. 1995. Drug Metab Dispos 23:190-196). Within 45 min of dosage
SENSITIVITY OF PROPRANOLOL ELIMINATION TO HYPOXIA IN THE ISOLATED PERFUSED RAT LIVER PREPARATION
โ Scribed by Susan L. Elliott; Denis J. Morgan; Peter W. Angus; Hany Ghabrial; Richard A. Smallwood
- Book ID
- 108935244
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 610 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0305-1870
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๐ SIMILAR VOLUMES
Although the adverse effect of hypoxia on drug metabolism is well documented in subcellular systems, its effect on drug clearance by the intact liver has not been defined. This study was undertaken in the isolated perfused rat liver to examine the effects of acute hypoxia on the hepatic elimination
The kinetics of hepatic elimination of the high-clearance drug propranolol has been interpreted in a previous study from our laboratory, in which propranolol protein binding was varied, to conform to the venous equilibrium model. In another study by a different group, in which perfusate flow was var