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SENSITIVITY OF PROPRANOLOL ELIMINATION TO HYPOXIA IN THE ISOLATED PERFUSED RAT LIVER PREPARATION

โœ Scribed by Susan L. Elliott; Denis J. Morgan; Peter W. Angus; Hany Ghabrial; Richard A. Smallwood


Book ID
108935244
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
610 KB
Volume
20
Category
Article
ISSN
0305-1870

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๐Ÿ“œ SIMILAR VOLUMES


Neonatal hepatic propranolol elimination
โœ Paul J. Gow; Saard Treepongkaruna; Hany Ghabrial; Arthur Shulkes; Richard A. Sma ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 209 KB ๐Ÿ‘ 2 views

Using the isolated perfused neonatal sheep liver model, we examined the disposition of propranolol (n โ€ซืกโ€ฌ 8, age 0.25-10 days) and compared our findings with our previous study from the perfused near-term fetal sheep liver (Ring JA, et al. 1995. Drug Metab Dispos 23:190-196). Within 45 min of dosage

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โœ D. Brian Jones; George W. Mihaly; Richard A. Smallwood; Lorraine K. Webster; Den ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 715 KB

Although the adverse effect of hypoxia on drug metabolism is well documented in subcellular systems, its effect on drug clearance by the intact liver has not been defined. This study was undertaken in the isolated perfused rat liver to examine the effects of acute hypoxia on the hepatic elimination

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The kinetics of hepatic elimination of the high-clearance drug propranolol has been interpreted in a previous study from our laboratory, in which propranolol protein binding was varied, to conform to the venous equilibrium model. In another study by a different group, in which perfusate flow was var