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The effect of homologous amino acid replacement on the conformation of oligopeptides. II. Synthesis of co-oligopeptides containing methionine and glycine

✍ Scribed by Jim Champi; Alvin S. Steinfeld; Fred Naider; Jeffrey M. Becker

Publisher
Wiley (John Wiley & Sons)
Year
1978
Tongue
English
Weight
856 KB
Volume
17
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The synthess of 18 co‐oligopeptides of L‐methionine and glycine is reported. A series of oligomers, Boc‐Gly‐Met~n~‐OMe (n = 1–6), and six hexamers‐containing five methionyl and one glycyl residue were synthesized using the mixed anhydride procedure. Polarimetric studies give evidence that oligomers in the Boc‐Gly‐Met~n~‐Ome series are essentially disordered in hexafluoroacetone sesquihydrate but begin forming secondry structures at n > 4 in trifluorethanol. Difference in the molar rotation values found for the six hexamers in hexafluoroacetone sesquihydrate may indicate that these compounds, while primirily disordered, are present in slightly different conformations.

📜 SIMILAR VOLUMES

The effect of homologous amino acid repl
The effect of homologous amino acid replacement on the conformation of oligopeptides. I. Synthesis of co-oligopeptides containing methionine and valine
✍ Jeffrey M. Becker; Fred Naider 📂 Article 📅 1978 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 520 KB

The preparation of a series of co-oligopeptides Boc-Val-Met,-OMe (n = 1-6), as well as Boc-Met3-Val-Metz-OMe and Boc-Met3-Val-Met3-0Me. is described. The synthesis was carried out by a classic method employing the mixed anhydride procedure (isobutylchloroformate) for all coupling reactions. All olig

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The effect of homologos amini acid replacement on the conformation of oligopeptides. III. CD studies on co-oligopeptides of methionine and valine or methionine and glycine in organic solution
✍ F. Naider; J. M. Becker; A. Ribeiro; M. Goodman 📂 Article 📅 1978 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 635 KB

## Abstract A conformational analyis of co‐ologopeptides containing methionine and valine or methionine and glycine was carried out using circular dichrosim. The oligopeptides containing valine and methionine (dimer to hexamer) are disorder in hexafluoropropane diol·0.5 H~2~O and trimethyl phospate

Co-oligopeptides of aromatic amino acids
Co-oligopeptides of aromatic amino acids and glycine with a variable distance between the aromatic residues. I. Synthesis of co-oligopeptides of tryptophan and glycine
✍ Rocco Guarnaccia; Gian Paolo Lorenzi; Vincenzo Rizzo; Pier Luigi Luisi 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 851 KB

## Abstract The preparation of the co‐oligopeptides of the series H‐Gly‐Trp‐(Gly)~__n__~‐Trp‐Gly‐OH (__n__ = 0, 1, and 2) and of a number of other unprotected co‐oligopeptides of glycine and tryptophan is reported. The syntheses have been carried out by conventional methods, using, in general, __N_

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Co-oligopeptides of aromatic amino acids and glycine with a variable distance between the aromatic residues. II. Ultraviolet absorption and circular dichroism properties of co-oligopeptides of tryptophan and glycine
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## Abstract The uv absorption and circular dichroism (CD) properties in water (pH 5.9) and trifluoroethanol of several co‐oligopeptides of glycine and tryptophan have been investigated. These compounds contain one tryptophyl residue, such as H‐Gly‐Trp‐OH, H‐Trp‐Gly‐OH, and H‐Gly‐Trp‐Gly‐OH; or two,

Co-oligopeptides of aromatic amino acids
Co-oligopeptides of aromatic amino acids and glycine with a variable distance between the aromatic residues. III. Co-oligopeptides of L-phenylalanine, L-tryptophan, and glycine: Synthesis and ultraviolet absorption properties
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## Abstract The preparation of the co‐oligopeptides of the series H‐Gly‐Phe‐(Gly)~__n__~‐Trp‐Gly‐OH (__n__ = 0, 1, 2) and of other free peptides of glycine, L‐tryptophan, and L‐phenylalanine is reported. The syntheses have been carried out by conventional methods, using __N__‐hydroxysuccinimide est

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Co-oligopeptides of aromatic amino acids and glycine with a variable distance between the aromatic residues. VI. Circular dichroism studies of co-oligopeptides of L-phenylalanine, L-tryptophan, and glycine
✍ Vincenzo Rizzo; Pier Luigi Luisi; Barbara Straub; Rocco Guarnaccia 📂 Article 📅 1977 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 694 KB

## Abstract The circular dichroic properties of H‐Gly‐Phe‐(Gly)~__n__~‐Trp‐Gly‐OH (II, __n__ = 0,1,2) and of related simpler peptides, such as H‐Phe‐Gly‐OH, H‐Gly‐Phe‐OH, H‐Gly‐Phe‐Gly‐OH, H‐Phe‐Trp‐OH, H‐Phe‐Trp‐Gly‐OH, and H‐Gly‐Phe‐Trp‐OH in water and trifluoroethanol solutions are investigated.