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The effect of homologous amino acid replacement on the conformation of oligopeptides. I. Synthesis of co-oligopeptides containing methionine and valine

✍ Scribed by Jeffrey M. Becker; Fred Naider

Publisher
Wiley (John Wiley & Sons)
Year
1978
Tongue
English
Weight
520 KB
Volume
17
Category
Article
ISSN
0006-3525

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✦ Synopsis

The preparation of a series of co-oligopeptides Boc-Val-Met,-OMe (n = 1-6), as well as Boc-Met3-Val-Metz-OMe and Boc-Met3-Val-Met3-0Me. is described. The synthesis was carried out by a classic method employing the mixed anhydride procedure (isobutylchloroformate) for all coupling reactions. All oligopeptides after purification were homogeneous on silica thin layers and gave correct elemental analysis. They were judged to be optically pure using molar rotation studies a t the sodium D line.

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