The effect of different lesions of the median raphe on morphine analgesia
โ Scribed by S. Romandini; E. Merlo Pich; E. Esposito; A. Kruszewska; R. Samanin
- Book ID
- 118871693
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 305 KB
- Volume
- 377
- Category
- Article
- ISSN
- 0006-8993
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๐ SIMILAR VOLUMES
Two different techniques were employed to measure morphine analgesia, the hot-plate and the tail compression. An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of brain noradrenaline and dopamine, strongly potentiated the analgesic effect of morphine. The lesion
The effects of lesions of the raphe nuclei on opiate-induced antinociception and brain serotonin (5-HT) levels were investigated. Lesions of the medial raphe nucleus effectively antagonized the analgesic effects of morphine, but not methadone, and lowered brain 5-HT. The decrement in analgesic activ