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Effects of medial raphe and raphe magnus lesions on the analgesic activity of morphine and methadone

✍ Scribed by William T. Chance; Glenn M. Krynock; John A. Rosecrans

Publisher: Springer
Year: 1978
Tongue: English
Weight: 523 KB
Volume: 56
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00431838

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of lesions of the raphe nuclei on opiate-induced antinociception and brain serotonin (5-HT) levels were investigated. Lesions of the medial raphe nucleus effectively antagonized the analgesic effects of morphine, but not methadone, and lowered brain 5-HT. The decrement in analgesic activity of morphine was reversed by pretreatment with 5-hydroxytryptophan. Lesions of the raphe magnus, a descending 5-HT system, antagonized the analgesic potency of both morphine and methadone. These experiments indicate a differential effect of 5-HT manipulation on opiate-induced analgesia, suggesting a different mechanism of analgesic action for morphine and methadone.

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