## Abstract The molecular size is found to play an important role in carbonic anhydrase (CA) inhibition by sulfonamides. Significant correlation is obtained between the inhibitory power of __meta__βsubstituted analogs and the van der Waals volume (__V__~__w__~) of the substitutents. This provides a
The effect of carbonic anhydrase inhibition on bicarbonate reabsorption
β Scribed by B. D. Slaughter; H. S. Osiecki; R. B. Cross
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 506 KB
- Volume
- 362
- Category
- Article
- ISSN
- 0031-6768
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π SIMILAR VOLUMES
Three isoenzymes of human carbonic anhydrase (HCA) have been described (designated HCA-I, HCA-I1 and HCA-111). HCA exists as a single polypeptide chain
## Abstract Carbonic anhydrase catalyzes reversible hydration of carbon dioxide and dehydration of bicarbonate. In this article we report that the rapid exchange catalyzed by carbonic anhydrase causes a large magnetization (saturation) transfer effect on the ^13^C signal of bicarbonate at 160.7 ppm
values of the curves m Fig 2 as Ki\_Css/H + 0 These asymptotes are mdicated tn the figure The effect of non-bear adsorptton on the second moment is noted to be large for higher values of KLCJH Also the effect increases as the rate constants (crL and y,,) decrease In principle, plots such as Fig 2 co