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Effect of molecular size on carbonic anhydrase inhibition by sulfonamides

✍ Scribed by Kamal Kumar; Mahesh C. Bindal; Prithvi Singh; Satya P. Gupta

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
310 KB
Volume
20
Category
Article
ISSN
0020-7608

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✦ Synopsis

Abstract

The molecular size is found to play an important role in carbonic anhydrase (CA) inhibition by sulfonamides. Significant correlation is obtained between the inhibitory power of meta‐substituted analogs and the van der Waals volume (V~w~) of the substitutents. This provides a theoretical basis to map the active sites in enzyme and find the nature of sulfonamide‐receptor binding. It is inferred that in addition to well known binding of sulfamyl group with Zn^2+^ ion of the enzyme, the meta substituent of sulfonamides interacts with some secondary binding site and this interaction is argued to be of van der Waals type.

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