## Abstract Interleukin‐1 receptor antagonist (IL‐1Ra) is a natural IL‐1 inhibitor, which competitively inhibits binding of IL‐1 to its receptors. IL‐1Ra is produced as four different isoforms, one secreted (sIL‐1Ra) and three intracellular (icIL‐1Ra1, 2, 3), derived from the same gene. We previous
The effect of an interleukin-1 receptor antagonist protein on type ii collagen–induced arthritis and antigen-induced arthritis in mice
✍ Scribed by Paul H. Wooley; Janey D. Whalen; Darryl L. Chapman; Ann E. Berger; Karen A. Richard; Danielle G. Aspar; Nigel D. Staite
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 988 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To investigate whether the soluble form of interleukin‐1 (IL‐1) receptor accessory protein (sIL‐1RAcP), whose physiologic function remains to be established, can serve as a specific inhibitor of IL‐1 signaling in vitro, and to evaluate its applicability in collagen‐induced
IL-1 is a key cytokine involved in the inflammatory response. The type II receptor of IL-1 (IL-1RII) acts as a decoy receptor, binding and inhibiting the effect of IL-1. This study was undertaken to establish whether IL-1RII can ameliorate collagen-induced arthritis, a model of inflammatory arthriti