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Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist

✍ Scribed by R. L. Smeets; L. A. B. Joosten; O. J. Arntz; M. B. Bennink; N. Takahashi; H. Carlsen; M. U. Martin; W. B. van den Berg; F. A. J. van de Loo

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
204 KB
Volume
52
Category
Article
ISSN
0004-3591

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Effectiveness of the soluble form of the interleukin-1 receptor accessory protein as an inhibitor of interleukin-1 in collagen-induced arthritis
✍ R. L. Smeets; F. A. J. van de Loo; L. A. B. Joosten; O. J. Arntz; M. B. Bennink; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 457 KB 👁 2 views

## Abstract ## Objective To investigate whether the soluble form of interleukin‐1 (IL‐1) receptor accessory protein (sIL‐1RAcP), whose physiologic function remains to be established, can serve as a specific inhibitor of IL‐1 signaling in vitro, and to evaluate its applicability in collagen‐induced