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The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

โœ Scribed by Yasutomo, Koji; Doyle, Carolyn; Miele, Lucio; Germain, Ronald N.


Book ID
109768137
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
419 KB
Volume
404
Category
Article
ISSN
0028-0836

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MHC specificity in positive selection is a major determinant in the CD4/CD8 T cell lineage decision. Previous studies support the view that quantitative differences in T cell receptor (TCR) signaling in immature CD4 + CD8 + double positive thymocytes leads to an instructive bias in CD4/CD8 T cell li