Distinct involvement of CD45 in antigen receptor signalling in CD4+ and CD8+ primary T cells
โ Scribed by Christiane R. Maroun; Michael Julius
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 771 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0014-2980
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๐ SIMILAR VOLUMES
Peripheral CD4 + T cells can be divided into two different functional populations based on the expression of distinct isoforms of the surface molecule CD45. We have investigated the differences in the proximal signaling induced by anti-CD3 monoclonal antibody in purified populations of "naive" CD45R
## Human CD4+CD45RO+ and CD4+CD45RA+ T cells synergize in response to alloantigens\* Alloantigens, unlike recall antigens, activate both CD45RA+ (naive) and CD45RO+ (memory) CD4+ cells to the same extent. These Tcell subsets may therefore interact with each other in response to alloantigens on tra