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Developmental regulation of αβ T cell antigen receptor assembly in immature CD4+CD8+ thymocytes

✍ Scribed by Kelly P. Kearse; Joseph P. Roberts; David L. Wiest; Alfred Singer


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
728 KB
Volume
17
Category
Article
ISSN
0265-9247

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Rat thymocytes of the T cell receptorlow (TcRIOW) CD4+8+ subset which is the target of repertoire selection are heterogeneous with respect to expression of the cell interaction (CI) molecules CD2, CD5, CDlldCD18 (LFA-l), CD28 and CD44. We show that this heterogeneity is due to the developmental regu