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The DNA-binding domain of HIV-1 integrase has an SH3-like fold

✍ Scribed by Eijkelenboom, Astrid P.A.M. ;Puras Lutzke, Ramon A. ;Boelens, Rolf ;Plasterk, Ronald H.A. ;Kaptein, Robert ;Hård, Karl


Book ID
109965118
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
531 KB
Volume
2
Category
Article
ISSN
1545-9993

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The structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy. The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a fivestranded ␤-barrel tha