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The diversity of T-cell receptor repertoire of peripheral CD4+ lymphocytes in LEC mutant rats

โœ Scribed by Y. Muramatsu; T. Agui; T. Sakai; T. Yamada; K. Matsumoto

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
535 KB
Volume
45
Category
Article
ISSN
0165-2478

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## Abstract LEC rats bear a congenital deficiency in CD4^+^CD8^โˆ’^ thymocytes and peripheral CD4^+^ T cells, and consequently a deficiency in T~h~ cell functions. Ontogeny of T cell maturation in normal and LEC mutant rats was, therefore, investigated. Prenatal development of thymocytes in normal ra