Bone marrow-derived progenitor T cells convey the origin of maturational arrest from CD4+CD8+ to CD4−CD8+ thymocytes in LEC mutant rats

Ontogeny of T cell maturation in LEC mut

Ontogeny of T cell maturation in LEC mutant rats which bear a congenital arrest of maturation from CD4+CD8+ to CD4+CD8− thymocytes

✍ Takashi Agui; Tohru Sakai; Kozo Matsumoto 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB 👁 1 views

## Abstract LEC rats bear a congenital deficiency in CD4^+^CD8^−^ thymocytes and peripheral CD4^+^ T cells, and consequently a deficiency in T~h~ cell functions. Ontogeny of T cell maturation in normal and LEC mutant rats was, therefore, investigated. Prenatal development of thymocytes in normal ra