๐”– Bobbio Scriptorium
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The discovery and development of zileuton: An orally active 5-lipoxygenase inhibitor

โœ Scribed by R.L. Bell; P.R. Young; D. Albert; C. Lanni; J.B. Summers; D.W. Brooks; P. Rubin; G.W. Carter


Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
425 KB
Volume
14
Category
Article
ISSN
0192-0561

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The 5-Lipoxygenase Inhibitory Activity o
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Leukotrienes are biologically active lipid mediators capable of producing airway inflammation, hyperresponsiveness and bronchoconstriction. The first enzyme in the metabolic pathway of arachidonic acid leading to the leukotrienes is 5-lipoxygenase (5-LO). A selective and potent 5-LO inhibitor, zileu