Discovery of a Potent, Selective and Orally Active Canine COX-2 Inhibitor, 2-(3-Difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.

5-Heteroatom Substituted Pyrazoles as Ca

5-Heteroatom Substituted Pyrazoles as Canine COX-2 Inhibitors. Part 1. Structure—Activity Relationship Studies of 5-Alkylamino Pyrazoles and Discovery of a Potent, Selective, and Orally Active Analogue.

✍ Subas M. Sakya; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 23 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

2-{2-[3-(Pyridin-3-yloxy)phenyl]-2H-tetr

2-{2-[3-(Pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine: A Highly Potent, Orally Active, Metabotropic Glutamate Subtype 5 (mGlu5) Receptor Antagonist.

✍ Dehua Huang; Steve F. Poon; Deborah F. Chapman; Janice Chung; Merryl Cramer; Tho 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 13 KB 👁 1 views

Identification of a Novel 3,5-Disubstitu

Identification of a Novel 3,5-Disubstituted Pyridine as a Potent, Selective, and Orally Active Inhibitor of Akt1 Kinase.

✍ Sheela A. Thomas; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 9 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform Abstract: 4-[5-Methyl-3-pheny

ChemInform Abstract: 4-[5-Methyl-3-phenylisoxazol-4-yl]benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2.

✍ John J. Talley; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

Discovery of [7-(2,6-Dichlorophenyl)-5-m

Discovery of [7-(2,6-Dichlorophenyl)-5-methylbenzo[1,2,4]triazin-3-yl]- [4-(2-pyrrolidin-1-ylethoxy)phenyl]amine — A Potent, Orally Active Src Kinase Inhibitor with Antitumor Activity in Preclinical Assays.

✍ Glenn Noronha; et al. et al. 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 13 KB

ChemInform Abstract: Discovery of N-[2-[

ChemInform Abstract: Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro-6- [3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl] -N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa.

✍ M. M. MORRISSEY; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

Discovery of a Potent, Selective and Orally Active Canine COX-2 Inhibitor, 2-(3-Difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.

✦ Synopsis

Abstract