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Preparative separation and analysis of the enantiomers of [14C]Zileuton, a 5-lipoxygenase inhibitor

✍ Scribed by Samuel B. Thomas; Bruce W. Surber; Mike Fitzgerald

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
371 KB
Volume
623
Category
Article
ISSN
1873-3778

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✍ Franz Oberdorfer; Thilo Siegel; Albrecht Guhlmann; Dietrich Keppler; Wolfgang Ma πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 French βš– 451 KB

## Abstract 5(S)‐Hydroxy‐6(R)‐(N‐[1‐^11^C]acetyl)cysteinyl‐7,9‐trans‐11,14‐cis‐eicosatetraenoic acid (N‐[1‐^11^C]acetyl leukotriene E~4~) was prepared by the reaction of leukotriene E~4~ and [1‐^11^C]acetyl chloride. The product was obtained with 1.3% yield, based on [1‐^11^C]acetyl chloride. The p