The disappearance of 14C-labelled isoenzyme 5 of L-lactate dehydrogenase from plasma
✍ Scribed by J.W. Boyd
- Book ID
- 115731534
- Publisher
- Elsevier Science
- Year
- 1967
- Weight
- 261 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0005-2744
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For metabolic studies in this Laboratory, 5-hydroxytryptamine (serotonin) labelled with I4C in the pyrrole part of the indole ring was required. Previous attempts to reach this compound through Madelung cyclization of 3-benzyloxy--6-formylaminotoluene failed (I), although this way proved to be succe
## Abstract The synthesis of selectively ^14^C‐labeled l‐tryptophan and its derivative 5‐hydroxy‐l‐tryptophan using chemical and multienzymatic methods is reported. The mixture containing [1‐^14^C[‐dl‐alanine, indole or 5‐hydroxyindole has been converted to [1‐^14^C]‐l‐tryptophan or 5′‐hydroxy‐[1‐^